CD329 (Siglec-9), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD329 (Siglec-9), Human |
| Clone | REA492 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | Vio Bright FITC conjugate |
| Size | 30 tests in 300 µL |
| Concentration | 1:11 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD329 (Siglec-9) Antibody, anti-human, Vio® Bright FITC, REAfinity™. Clone REA492 recognizes the human CD329 antigen, a single-pass type I membrane protein also known as sialic acid-binding Ig-like lectin 9 (Siglec-9). Siglecs are characterized by an amino-terminal V-set immunoglobulin domain that binds to sialic acid residues, followed by a variable number of C2-set immunoglobulin-like domains. CD329 is expressed quite broadly among human blood leukocytes, being found on monocytes, neutrophils, B cells, NK cells, and minor subsets of T cells. Ligation of CD329 induced apoptosis in adult neutrophils in a caspase-dependent manner; in contrast, its activation under inflammatory conditions resulted in a caspase-independent autophagic type of cell death. These disparate actions implicate a unique role for CD329 in modulating cell survival under inflammatory and basal conditions. | Additional information: Clone REA492 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | CDw329, FOAP-9, OBBP-LIKE, Siglec-9 |
| Gene, Accession # | Gene ID: 27180 |
| Catalog # | 130-107-651 |
| Price | $158 |
| Order / More Info | CD329 (Siglec-9), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Tanida, S. et al. (2013) Binding of the sialic acid-binding lectin, Siglec-9, to the membrane mucin, MUC1, induces recruitment of β-catenin and subsequent cell growth. J. Biol. Chem. 288 (44): 31842-31852. | Zhang, J. Q. et al. (2000) Siglec-9, a novel sialic acid binding member of the immunoglobulin superfamily expressed broadly on human blood leukocytes. J. Biol. Chem. 275 (29): 22121-22126. | Foussias, G. et al. (2000) Identification and molecular characterization of a novel member of the siglec family (SIGLEC9). Genomics 67 (2): 171-178. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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