CD172a (SIRPα), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD172a (SIRPα), Mouse |
| Clone | REA1201 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | PerCP-Vio 700 conjugate |
| Size | 30 µg in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD172a (SIRPα) Antibody, anti-mouse, PerCP-Vio® 700, REAfinity™. Clone REA1201 recognizes the mouse antigen CD172a, a 75-110 kDa glycosylated receptor-like protein, which is also known as SIRPα or SHPS-1. CD172a promotes the attachment and neurite outgrowth of cultured murine cerebellar cells. It binds to its ligand CD47, which inhibits cytokine production by mature dendritic cells (DCs) and avoids maturation of immature DCs. CD172a plays a role in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors, or insulin and mediates negative regulation of phagocytosis, mast cell, and DC activation. CD172a is strongly expressed by neurons and myeloid cells, such as monocytes, macrophages, granulocytes, and DCs in several tissues, e.g., cerebral cortex, brain, spinal cord, cerebellum, and spleen. CD172a is not expressed on oligodendrocytes or GFAP-positive astrocytes. | Additional information: Clone REA1201 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | SHPS-1, SIRPα, P84, Sirpa, Bit, Myd1, Ptpns1, Shps1, Sirp |
| Gene, Accession # | Gene ID: 19261 |
| Catalog # | 130-123-156 |
| Price | $165 |
| Order / More Info | CD172a (SIRPα), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Chuang, W. et al. (1990) Central nervous system antigen P84 can serve as a substrate for neurite outgrowth. Dev. Biol. 137 (2): 219-232. | Comu, S. et al. (1997) The murine P84 neural adhesion molecule is SHPS-1, a member of the phosphatase-binding protein family. J. Neurosci. 17 (22): 8702-8710. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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