CD80, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD80, Human |
| Clone | REA661 |
| Host Species | Recombinant Human |
| Reactive Species | human, nonhuman primate |
| Isotype | IgG1 |
| Format | phycoerythrin (PE) conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD80 Antibody, anti-human, PE, REAfinity™. Clone REA661 recognizes the human CD80 antigen, also known as B7-1. CD80 is a 262 amino acid long 60 kDa molecule and a member of the immunoglobulin superfamily. Together with CD86 (B7-2) it belongs to the B7 family of costimulatory molecules. CD80 is expressed on activated B cells, dendritic cells, and monocytes/ macrophages. The interaction of CD80 with its ligands CD28 and CD152 (CTLA-4) plays a critical role in induction and regulation of immune responses. Binding of CD80 to CD28, which is constitutively expressed on T cells, provides a costimulatory signal and induces T cell proliferation and cytokine production. In contrast, binding to CTLA-4 strongly inhibits proliferation and IL-2 secretion by T cells. | Additional information: Clone REA661 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | B7, B7-1, BB1 |
| Gene, Accession # | Gene ID: 941 |
| Catalog # | 130-123-314 |
| Price | $119 |
| Order / More Info | CD80, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Freeman, G. J. et al. (1989) B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells. J Immunol 143 (8): 2714-2722. | Lanier, L. L. et al. (1995) CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL. J Immunol 154 (1): 97-105. | Krummel, M. F. and Allison, J. P. (1995) CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J. Exp. Med. 182 (2): 459-465. | Linsley, P. S. et al. (1993) The role of the CD28 receptor during T cell responses to antigen. Annu. Rev. Immunol. 11: 191-212. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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