CD32, Rat Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD32, Rat |
| Clone | REA256 |
| Host Species | Recombinant Human |
| Reactive Species | rat |
| Isotype | IgG1 |
| Format | phycoerythrin (PE) conjugate |
| Size | 30 µg in 1 mL |
| Concentration | 1:10 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD32 Antibody, anti-rat, PE, REAfinity™. Clone REA256 recognizes the CD32 antigen, a 40 kDa polymorphic transmembrane glycoprotein also known as low affinity immunoglobulin gamma Fc region receptor II (FcγRII or FCRII). CD32 is a surface receptor protein and part of a large population of B cell co-receptors, which act to modulate signaling. Rat CD32 is expressed by B lymphocytes, myeloid cells, some lymphocytes in the thymic medulla, and cells which appear homologous to plasmacytoid dendritic cells. It mediates phagocytosis and oxidative burst in granulocytes, as well as platelet aggregation and immunomodulation. The extracellular domain of CD32 binds to aggregated IgG and immune complexes and down-regulates antibody production in the presence of IgG. This feedback loops essentially lowers the production of IgG produced by B cells when there is a surplus in the body. | Additional information: Clone REA256 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | FCGR2B, FcRII, FcgammaRIIB2, Fcgr2 |
| Gene, Accession # | Gene ID: 289211 |
| Catalog # | 130-102-749 |
| Price | $66 |
| Order / More Info | CD32, Rat Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Hubert, F. X. et al. (2004) Rat plasmacytoid dendritic cells are an abundant subset of MHC Class II+ CD4+CD11b-OX62- and type I IFN-producing cells that exhibit selective expression of Toll-like receptors 7 and 9 and strong responsiveness to CpG. J Immunol 172 (12): 7485-7494. | Lynch, R. G. et al. (2000) Regulatory roles for FcgammaRIII (CD16) and FcgammaRII (CD32) in the development of T- and B-lineage lymphoid cells. J. Leukoc. Biol. 67: 279-284. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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