CD40, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD40, Human |
| Clone | HB14 |
| Host Species | Mouse |
| Reactive Species | human, nonhuman primate |
| Isotype | IgG1κ |
| Format | PE-Vio 770 conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Functional assay |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD40 Antibody, anti-human, PE-Vio® 770. The HB14 monoclonal antibody reacts with human CD40, a 45-50 kDa type I transmembrane glycoprotein and member of the tumor necrosis factor receptor (TNFR) superfamily. It is expressed primarily on B cells, macrophages, dendritic cells, endothelial cells, and fibroblasts and at lower levels on plasma cells and a subset of peripheral T cells. CD40 is involved in B cell differentiation and proliferation, isotype class-switching, and protection of B cells from apoptosis. Interaction of CD40 with its ligand CD154 is important in T cell-B cell interaction and plays a role in co-stimulation and immune regulation. Clone HB14 blocks the binding of CD40 to CD154. |
| Immunogen | n/a |
| Other Names | Bp50, CDW40, TNFRSF5, p50 |
| Gene, Accession # | Gene ID: 958 |
| Catalog # | 130-117-716 |
| Price | $365 |
| Order / More Info | CD40, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Kansas, G. S. et al. (1991) Transmembrane signals generated through MHC class II, CD19, CD20, CD39, and CD40 antigens induce LFA-1-dependent and independent adhesion in human B cells through a tyrosine kinasedependent pathway. J Immunol 147 (12): 4094-4102. | Banchereau, J. et al. (1994) The CD40 antigen and its ligand. Annu. Rev. Immunol. 12: 881-926. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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