CD195 (CCR5), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD195 (CCR5), Human |
| Clone | REA245 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | phycoerythrin (PE) conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD195 (CCR5) Antibody, anti-human, PE, REAfinity™. Clone REA245 recognizes the human CD195 antigen, a multi-pass membrane protein which is also known as C-C chemokine receptor type 5 (CCR5). CD195 belongs to the G-protein coupled receptor 1 family and is predominantly expressed on T cells, macrophages, and dendritic cells. It is a receptor for a number of inflammatory CC-chemokines including MIP-1-α, MIP-1-β, and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. CD195 is involved in the chemotaxis of leucocytes to inflammation sites and plays an important role in the recruitment of macrophages, T cells, and monocytes in inflammation. Many forms of HIV initially use CD195 to enter and infect host cells. Additionally, CCR5 may have an indirect effect on cancer progression by controlling the antitumor immune response, since it has been demonstrated that its expression could promote tumor growth and contribute to tumor metastasis. | Additional information: Clone REA245 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | CCR5, CC-CKR-5, CCCKR5, CCR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22, CHEMR13 |
| Gene, Accession # | Gene ID: 1234 |
| Catalog # | 130-117-506 |
| Price | $121 |
| Order / More Info | CD195 (CCR5), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Richardson, M. W. et al. (2012) Kruppel-like factor 2 modulates CCR5 expression and susceptibility to HIV-1 infection. J Immunol 189 (8): 3815-3821. | Shahin, K. et al. (2013) Alterations in chemokine receptor CCR5 expression on blood dendritic cells correlate with acute graft-versus-host disease. Transplantation 96 (8): 753-762. | Samson, M. et al. (1996) Molecular cloning and functional expression of a new human CC-chemokine receptor gene. Biochemistry 35 (11): 3362-3367. | Li, W. et al. (2016) Proteomics analysis reveals a T?17-prone cell population in presymptomatic graft-versus-host disease. JCI Insight 1 (6): e86660. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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