TCR Vα7.2, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | TCR Vα7.2, Human |
| Clone | REA179 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | PerCP-Vio 700 conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | TCR Vα7.2 Antibody, anti-human, PerCP-Vio® 700, REAfinity™. Clone REA179 recognizes the TCR chain Vα7.2, which together with Jα33 segment forms the invariant T cell receptor. Human Vα7.2-Jα33 invariant T cells are preferentially localized in the gut and are often termed as mucosal-associated T (MAIT) cells. MAIT cells are restricted to MHC class I like molecules, such as MR1. Further, MAIT cells are suggested to be involved in regulation of immune response at the mucosal surfaces, which are the primary sites for pathogen entry. | Additional information: Clone REA179 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | TRA, IMD7, TCRA, TCRD, TRA, TRAC, TCRAV7S1, TRAV7 |
| Gene, Accession # | Gene ID: 28686 |
| Catalog # | 130-123-906 |
| Price | $365 |
| Order / More Info | TCR Vα7.2, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Treiner, E. et al. (2003) Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1. Nature 422 (6928): 164-169. | Wang, Y. et al. (2016) Dual T cell- and B cell-intrinsic deficiency in humans with biallelic RLTPR mutations. J. Exp. Med. 213 (11): 2413-2435. | Qualai, J. et al. (2016) Expression of CD11c is associated with unconventional activated T cell subsets with high migratory potential. PLoS One 11 (4): e0154253. | Gold, M. C. and Lewinsohn, D. M. (2013) Co-dependents: MR1-restricted MAIT cells and their antimicrobial function. Nat. Rev. Microbiol. 11 (1): 14-19. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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