MEK1, Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | MEK1, Human/Mouse |
| Clone | REA155 |
| Host Species | Recombinant Human |
| Reactive Species | human, mouse |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 30 tests in 300 µL |
| Concentration | 1:11 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | MEK1 Antibody, anti-human/mouse, APC, REAfinity™. Clone REA155 recognizes MEK1, a 45 KDa serine/threonine kinase and a component of the MAPK signal transduction cascade. In response to ligands such as growth factors, cytokines, and hormones, respective cell surface receptors are engaged and activate GTP-bound Ras, which transmits the signal by activating the protein kinases Raf-1, B-Raf, and A-Raf (Rafs), the MAP3K components of the cascade. MEK1 and the related kinase MEK2 are then the targets of MAP3K and transmit the signal further by phosphorylating the MAP kinases ERK1/ERK2. MAPK signal transduction pathway is involved in large variety of processes including cell adhesion, cell cycle progression, cell migration, cell survival, differentiation, metabolism, proliferation, and transcription. | Additional information: Clone REA155 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | MAP2K1, CFC3, MAPKK 1, MKK1, PRKMK1 |
| Gene, Accession # | Gene ID: 5604 |
| Catalog # | 130-101-080 |
| Price | $142 |
| Order / More Info | MEK1, Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Roskoski, R. et al. (2012) MEK1/2 dual-specificity protein kinases: structure and regulation. Biochem. Biophys. Res. Commun. 417 (1): 5-10. | Davis, R. J. et al. (1995) Transcriptional regulation by MAP kinases. Mol. Reprod. Dev. 42 (4): 459-467. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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