HLA-B7, B27, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | HLA-B7, B27, Human |
| Clone | REA176 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | APC-Vio 770 conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | HLA-B7, B27 Antibody, anti-human, APC-Vio® 770, REAfinity™. Clone REA176 recognizes HLA B7 and B27 class I human leukocyte antigens (HLA). Expressed on the surface of most nucleated cells, class I molecules are heterodimeric molecules and consist of a type I integral membrane α heavy chain and soluble β2 microglobulin protein. The extracellular region of the heavy chain further consists of three domains, of which one comprises the peptide binding groove. Antigens binding to class I molecules are 8-10 amino acids long and play an important role in recognition of the virus infected and malignant cells by cytotoxic T lymphocytes (CTLs). In addition, class I molecules interact with NK cell receptors to modulate the activity of NK cells. HLA-B7 is a risk factor for cervical cancer, sarcoidosis, and early-onset spondylarthropathies. HLA-B27 is known for its strong association with inflammatory spondyloarthropathies. It has been also discovered as a protective factor against some severe viral infections. | Additional information: Clone REA176 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | HLA-B, AS, SPDA1 |
| Gene, Accession # | Gene ID: 3106 |
| Catalog # | 130-129-849 |
| Price | $166 |
| Order / More Info | HLA-B7, B27, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Akram, A. et al. (2014) HLA-B27, but not HLA-B7, immunodominance to influenza is ERAP dependent. J Immunol 192 (12): 5520-5528. | Akram, A. et al. (2013) Co-expression of HLA-B7 and HLA-B27 alleles is associated with B7-restricted immunodominant responses following influenza infection. Eur. J. Immunol. 43 (12): 3254-3267. | den Uyl, D. et al. (2004) Progression of HIV to AIDS: a protective role for HLA-B27? AIDS Rev. 6 (2): 89-96. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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