CD157 (BST-1), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD157 (BST-1), Human |
| Clone | REA465 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | PerCP-Vio 700 conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD157 (BST-1) Antibody, anti-human, PerCP-Vio® 700, REAfinity™. Clone REA465 recognizes the human CD157 antigen, a glycosylphosphatidylinositol (GPI) linked protein, which is also known as bone marrow stromal antigen 1 (BST-1) or cyclic ADP-ribose hydrolase 2. CD157, a member of the CD38 gene family, is an NAD-metabolizing ectoenzyme and a signaling molecule, which synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, former a second messenger that elicits calcium release from intracellular stores. It is mainly expressed by cells of the myeloid lineage, bone marrow stroma, and vascular endothelium. CD157 is also expressed by ovarian cancer epithelium and by peritoneal mesothelial cells, where it is implicated in tumor dissemination. Further, it is endowed with receptor-like features observed in different cell types and transduces signals by interacting with transmembrane partner molecules, a strategy shared by other GPI-anchored molecules. CD157 is involved in neutrophil polarization, adhesion, and motility and controls transendothelial migration. | Additional information: Clone REA465 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | BST-1 |
| Gene, Accession # | Gene ID: 683 |
| Catalog # | 130-130-006 |
| Price | $400 |
| Order / More Info | CD157 (BST-1), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Kaisho, T. et al. (1994) BST-1, a surface molecule of bone marrow stromal cell lines that facilitates pre-B-cell growth. Proc. Natl. Acad. Sci. U.S.A. 91 (12): 5325-5329. | Ishihara, K. et al. (2000) BST-1/CD157 regulates the humoral immune responses in vivo. Chem. Immunol. 75: 235-255. | Morone, S. et al. (2014) Binding of CD157 protein to fibronectin regulates cell adhesion and spreading. J. Biol. Chem. 289 (22): 15588-15601. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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