p53, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | p53, Human |
| Clone | REA1132 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | fluorescein (FITC) conjugate |
| Size | 200 µL |
| Concentration | 1:50 |
| Applications | MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | p53 Antibody, anti-human, FITC, REAfinity™. Clone REA1132 recognizes the human cellular tumor antigen p53. The p53 protein is an important regulator of cell growth and, thus, functions as a tumor suppressor in many tumor types. The p53 tumor suppressor gene is altered or deleted in most solid human tumors. It is tightly regulated and plays a critical role in the cellular response to environmental stress. Upon a cell's exposure to stress, such as hypoxia or genomic damage, the p53 protein is expressed at high levels and is post-translationally modified. These modifications, which include phosphorylation, acetylation, and glycosylation occur rapidly and lead to the activation of p53, resulting in either G1 growth arrest or programmed cell death. | Additional information: Clone REA1132 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | BCC7, LFS1, P53, TRP53 |
| Gene, Accession # | Gene ID: 7157 |
| Catalog # | 130-119-501 |
| Price | $270 |
| Order / More Info | p53, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Zakut-Houri, R. et al. (1985) Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells. EMBO J. 4 (5): 1251-1255. | Lamb, P. et al. (1986) Characterization of the human p53 gene. Mol. Cell. Biol. 6 (5): 1379-1385. | Stiewe, T. (2007) The p53 family in differentiation and tumorigenesis. Nat. Rev. Cancer 7 (3): 165-168. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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