CD120a (TNF-RI), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD120a (TNF-RI), Human |
| Clone | REA252 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | biotin conjugate |
| Size | 30 tests in 300 µL |
| Concentration | 1:11 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD120a (TNF-RI) Antibody, anti-human, Biotin, REAfinity™. Clone REA252 recognizes the extracellular part of the membrane-bound and soluble form of the CD120a antigen, a 55 kDa type I transmembrane glycoprotein also known as tumor necrosis factor receptor type I (TNF-RI) or p55. CD120a belongs to the TNF receptor superfamily and is mainly expressed by monocytes, macrophages, and neutrophils. It is also expressed by a variety of cell lines, tumor cells, and normal cell types including T cells, endothelial cells, hepatocytes, chondrocytes, and fibroblasts. Binding of TNF-α to its main receptor CD120a triggers signaling which is extremely complex, leading to both cell death and survival signals. Sustained activation of TNF signaling has been implicated in the pathogenesis of a wide spectrum of human diseases, including cancer, osteoporosis, sepsis, diabetes, and autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease. | Additional information: Clone REA252 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | TNFRSF1A, FPF, MS5, TBP1, p55, p60, TNF-R1 |
| Gene, Accession # | Gene ID: 7132 |
| Catalog # | 130-106-358 |
| Price | $99 |
| Order / More Info | CD120a (TNF-RI), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Grell, M. et al. (1998) The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor. Proc. Natl. Acad. Sci. U.S.A. 95: 570-575. | Bianchi, K. et al. (2009) A tangled web of ubiquitin chains: breaking news in TNF-R1 signaling. Mol. Cell 36 (5): 736-742. | Hijdra, D. et al. (2012) Differential expression of TNFR1 (CD120a) and TNFR2 (CD120b) on subpopulations of human monocytes. J. Inflamm. 9 (1): 38. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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