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Antigenic Specificity | CD103, Mouse |
Clone | 2E7 |
Host Species | Hamster |
Reactive Species | mouse |
Isotype | IgG |
Format | fluorescein (FITC) conjugate |
Size | 30 µg in 200 µL |
Concentration | 1:50 |
Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD103 Antibody, anti-mouse, FITC. Armenian hamster IgG Clone 2E7 reacts with mouse CD103, a 175 kDa large, type I transmembrane glycoprotein also known as αE integrin. CD103 associates non-covalently with integrin β7 thereby forming the heterodimeric integrin αEβ7. It mediates cell-cell contact and is involved in homing processes by binding to its ligand e-cadherin. CD103 is expressed on >90% of intestinal intraepithelial lymphocytes (IEL), epithelial T cells, and regulatory T cells. Due to its differential expression on dendritic cells from peripheral tissues, it is useful in identifying dendritic cell subsets from intestinal lamina propria, lung, and dermis. |
Immunogen | n/a |
Other Names | ITGAE, aM290, alpha-E1, alpha-M290, integrin alpha E |
Gene, Accession # | Gene ID: 16407 |
Catalog # | 130-118-681 |
Price | $54 |
Order / More Info | CD103, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Sung, S. S. et al. (2006) A major lung CD103 alphaE-beta7 integrin-positive epithelial dendritic cell population expressing Langerin and tight junction proteins. J Immunol 176 (9): 2161-2172. | Bogunovic, M. et al. (2009) Origin of the lamina propria dendritic cell network. Immunity 31 (3): 513-525. | Ginhoux, F. et al. (2007) Blood-derived dermal Langerin+ dendritic cells survey the skin in the steady state. J. Exp. Med. 204 (13): 3133-3146. |