ChemR23 (CMKLR1), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | ChemR23 (CMKLR1), Mouse |
| Clone | REA461 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | biotin conjugate |
| Size | 30 µg in 1 mL |
| Concentration | 1:10 |
| Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | ChemR23 (CMKLR1) Antibody, anti-mouse, Biotin, REAfinity™. Clone REA461 recognizes the mouse G-protein coupled receptor ChemR23 antigen, a multi-pass membrane protein, which is also known as chemokine-like receptor 1 (CMKLR1). During dendritic cell (DC) differentiation from bone marrow, ChemR23 is upregulated early and then diminishes with time in culture. Most DC in vivo do not detectably express the receptor. In contrast, freshly isolated F4/80+/CD11b+ mouse peritoneal macrophages express ChemR23, display calcium signaling and migration to the active ligand. A small population of blood-borne F4/80+/CD11b+ macrophages also expresses ChemR23. Its natural ligand, chemerin, acts as a chemoattractant agent for leukocytes expressing ChemR23. Activation of ChemR23 results in intracellular calcium release, inhibition of cAMP accumulation and phosphorylation of ERK-1/ERK-2 MAP kinases. ChemR23 positively regulates adipogenesis and adipocyte metabolism. | Additional information: Clone REA461 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | Cmklr1, Dez, Gpcr27, mcmklr1 |
| Gene, Accession # | Gene ID: 14747 |
| Catalog # | 130-106-949 |
| Price | $59 |
| Order / More Info | ChemR23 (CMKLR1), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Zabel, B. A. et al. (2006) Chemokine-like receptor 1 expression by macrophages in vivo: regulation by TGF-beta and TLR ligands. Exp. Hematol. 34 (8): 1106-1114. | Bondue, B. et al. (2012) The chemerin/ChemR23 system does not affect the pro-inflammatory response of mouse and human macrophages ex vivo. PLoS One 7 (6): 400-443. | Rouger, L. et al. (2013) ChemR23 knockout mice display mild obesity but no deficit in adipocyte differentiation. J. Endocrinol. 219 (3): 279-289. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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