TIM-3, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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|---|---|
| Antigenic Specificity | TIM-3, Human |
| Clone | REAL818 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | n/a |
| Format | phycoerythrin (PE) conjugate |
| Size | 200 µL |
| Concentration | n/a |
| Applications | MICS (MACSima Imaging Cyclic Staining), Immunohistochemistry, Immunofluorescence |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | TIM-3 Antibody, anti-human, PE, REAdye_lease™. Clone REAL818 is an antibody fragment derived from the full TIM-3 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity. | Clone REAL818 recognizes the TIM-3 antigen, a Single-pass type I membrane protein which is also known as CD366, T cell immunoglobulin and mucin domain containing protein-3 (TIM-3) or Hepatitis A virus cellular receptor 2 (HAVcr-2). TIM-3 is expressed on activated T cells, especially T?1 cells, monocytes, macrophages, and dendritic cells. It is an activation-induced inhibitory molecule involved in tolerance and shown to induce T-cell exhaustion in chronic viral infection and cancers. CD366 has been proposed to inhibit T?1-mediated immune responses and regulates T?1 and T?17 cytokine secretion. The interaction of TIM-3 and its ligand galectin-9 induces apoptosis of T?1 cells. | For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675). |
| Immunogen | n/a |
| Other Names | HAVcr-2, TIMD-3, Tim3, CD366 |
| Gene, Accession # | n/a |
| Catalog # | 130-125-682 |
| Price | $420 |
| Order / More Info | TIM-3, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Monney, L. et al. (2002) T?1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature 415: 536-541. | Zhu, C. et al. (2005) The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. Nat Immunol 6 (12): 1245-1252. | van de Weyer, P. S. et al. (2006) A highly conserved tyrosine of Tim-3 is phosphorylated upon stimulation by its ligand galectin-9. Biochem. Biophys. Res. Commun. 351 (2): 571-576. | Hastings, W. D. et al. (2009) TIM-3 is expressed on activated human CD4+ T cells and regulates T?1 and T?17 cytokines. Eur. J. Immunol. 39 (9): 2492-2501. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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