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Antigenic Specificity | Ly-49A/D, Mouse |
Clone | REA853 |
Host Species | Recombinant Human |
Reactive Species | mouse |
Isotype | IgG1 |
Format | biotin conjugate |
Size | 150 µg in 1 mL |
Concentration | 1:50 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Ly-49A/D Antibody, anti-mouse, Biotin, REAfinity™. Clone REA853 recognizes the mouse Ly-49A and Ly-49D antigens belonging to the Ly-49 family. Members of Ly-49 family are homodimeric C-type lectin receptors, recognizing MHC class I molecules as ligands, and include activating and inhibitory receptor molecules. Ly-49A is a 44 kDa type II transmembrane, disulfide-linked homodimer with C-type lectin extracellular domains. Expression of Ly-49A is found on subset of NK and NK T cells. Ly-49D is a prototypic activating member of Ly-49 family and in contrast to inhibitory members, lacks a cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM). A positive signal is initiated by interaction of Ly-49D with immunoreceptor tyrosine-based activating motif (ITAM) containing transmembrane adapter DAP12. | Clone REA853 does not react with BALB/c, DBA/2, AKR, or CBA/J Ly-D49D. | Additional information: Clone REA853 displays negligible binding to Fc receptors. |
Immunogen | n/a |
Other Names | Ly49A, Ly49D |
Gene, Accession # | Gene ID: 16627, 16635 |
Catalog # | 130-112-748 |
Price | $202 |
Order / More Info | Ly-49A/D, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Yokoyama, W. M. et al. (1993) The Ly-49 and NKR-P1 gene families encoding lectin-like receptors on natural killer cells: the NK gene complex. Annu. Rev. Immunol. 11: 613-635. | Mason, L. H. et al. (1996) The Ly-49D receptor activates murine natural killer cells. J. Exp. Med. 184: 2119-2128. | Takei, F. et al. (1997) The Ly-49 family: genes, proteins and recognition of class I MHC. Immunol. Rev. 155: 67-77. | Ortaldo, J. R. et al. (1998) The Ly-49 family: regulation of cytotoxicity and cytokine production in murine CD3+ cells. J Immunol 160 (3): 1158-1165. | Ortaldo, J. R. et al. (1999) Ly-49 receptor expression and functional analysis in multiple mouse strains. J. Leukoc. Biol. 66 (3): 512-520. | Hanke, T. et al. (1999) Direct assessment of MHC class I binding by seven Ly49 inhibitory NK cell receptors. Immunity 11 (1): 67-77. | Chung, D. H. et al. (2000) Mapping the ligand of the NK inhibitory receptor Ly49A on living cells. J Immunol 165: 6922-6932. |