CD295 (LEPR), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD295 (LEPR), Human |
| Clone | REA361 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | PE-Vio 770 conjugate |
| Size | 100 tests in 1 mL |
| Concentration | 1:11 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD295 (LEPR) Antibody, anti-human, PE-Vio® 770, REAfinity™. Clone REA361 recognizes the human CD295 antigen, a single-pass type I membrane protein which is also known as leptin receptor (LEPR). CD295 is a member of the type I cytokine receptor family which acts through Janus kinases and signal transducers and activators of transcription. It is predominantly expressed in the central nervous system and in multiple tissues, including the choroid plexus, lung, kidney, and primitive hematopoietic cell populations. CD295 is the receptor for leptin, a peptide hormone which is secreted by the adipose tissue at levels roughly proportional to fat content. Leptin communicates the repletion of peripheral energy stores to the brain, suppressing feeding and permitting/promoting energy expenditure via a variety of neuroendocrine and autonomic mechanisms. | Additional information: Clone REA361 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | LEPR, LEP-R, LEPRD, OB-R, OBR, HuB219 (B219) |
| Gene, Accession # | Gene ID: 3953 |
| Catalog # | 130-105-153 |
| Price | $350 |
| Order / More Info | CD295 (LEPR), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Tartaglia, L. A. et al. (1995) Identification and expression cloning of a leptin receptor, OB-R. Cell 83 (7): 1263-1271. | Cioffi, J. A. et al. (1996) Novel B219/OB receptor isoforms: possible role of leptin in hematopoiesis and reproduction. Nat Med 2 (5): 585-589. | Villanueva, E. C. et al. (2008) Leptin receptor signaling and the regulation of mammalian physiology. Int. J. Obes. (Lond.) 32 (7): 8-12. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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