HLA-DR, DP, DQ, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | HLA-DR, DP, DQ, Human |
| Clone | REA332 |
| Host Species | Recombinant Human |
| Reactive Species | human, nonhuman primate |
| Isotype | IgG1 |
| Format | fluorescein (FITC) conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry, Immunocytochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | HLA-DR, DP, DQ Antibody, anti-human, FITC, REAfinity™. Clone REA332 recognizes all major histocompatibility class (MHC) class II HLA-DR, DP, and most DQ antigens. Expressed on the surface of most nucleated cells, MHC class II molecules play an important role in the immune system. They are essential in the defense against infection and are a main consideration in transplantation medicine. In addition to presenting antigenic peptides from predominantly extracellular sources to CD4+ T cells, MHC class II molecules also mediate the thymic selection of T helper cells. MHC class II molecules consist of an α and β chain and are transported to endosomal-lysosomal compartments by the invariant chain. In humans, MHC class II molecules are encoded by three different loci, HLA-DR, -DQ, and -DP, which display 70% similarity to each other. Despite the essential function of MHC class II molecules in immune defense against pathogens, some alleles are frequently linked to immune diseases. | Additional information: Clone REA332 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DQB3, HLA-DRA, HLA-DRB1 |
| Gene, Accession # | Gene ID: 3123, 3122, 3127, 3126, 3125, 16149, 3115, 3113, 3117, 3118, 3119, 3120, 3121 |
| Catalog # | 130-123-695 |
| Price | $265 |
| Order / More Info | HLA-DR, DP, DQ, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Denzin, L. et al. (2017) Neutralizing antibody responses to viral infections are linked to the non-classical MHC class II gene H2-Ob. Immunity 47 (2): 310-322. | van Lith, M. et al. (2010) HLA-DP, HLA-DQ, and HLA-DR have different requirements for invariant chain and HLA-DM. J. Biol. Chem. 285 (52): 40800-40808. | Franchini, G. et al. (2018) HIV vaccine candidate activation of hypoxia and the inflammasome in CD14+ monocytes is associated with a decreased risk of SIVmac251 acquisition. Nat Med 24 (6): 847-856. | Jones, E. Y. et al. (2006) MHC class II proteins and disease: a structural perspective. Nat. Rev. Immunol. 6 (4): 271-282. | Nishimura, Y. et al. (1998) Peptide-based molecular analyses of HLA class II-associated susceptibility to autoimmune diseases. Int. Rev. Immunol. 17 (5-6): 229-262. | Hoppstadter, J. et al. (2015) M2 polarization enhances silica nanoparticle uptake by macrophages. Front Pharmacol 6: 55. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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