CD46, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD46, Human |
| Clone | REA312 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | biotin conjugate |
| Size | 30 tests in 300 µL |
| Concentration | 1:11 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD46 Antibody, anti-human, Biotin, REAfinity™. Clone REA312 recognizes the human CD46 antigen, a type I transmembrane glycoprotein, which is also known as the membrane cofactor protein (MCP). At least fourteen different transcript variants encoding different isoforms have been found for CD46. It is expressed by a broad range of tissues including leukocytes, platelets, epithelial cells, and fibroblasts, but not by erythrocytes. CD46 acts as a co-factor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It is involved in the fusion of the spermatozoa with the oocyte during fertilization. Additionally, CD46 functions as a receptor for measles virus, human herpesvirus, and human adenovirus. It is a potent costimulator for the induction of interferon-γ secreting effector T helper type 1 cells and their subsequent switch into interleukin 10 producing regulatory T cells. | Additional information: Clone REA312 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | Membrane cofactor protein (MCP), AHUS2, MCP, MIC10, TLX, TRA2.10 |
| Gene, Accession # | Gene ID: 4179 |
| Catalog # | 130-105-585 |
| Price | $99 |
| Order / More Info | CD46, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Le Friec, G. et al. (2012) The CD46-Jagged1 interaction is critical for human T?1 immunity. Nat Immunol 13 (12): 1213-1221. | Dorig, R. E. et al. (1993) The human CD46 molecule is a receptor for measles virus (Edmonston strain). Cell 75 (2): 295-305. | Purcell, D. F. et al. (1991) Alternatively spliced RNAs encode several isoforms of CD46 (MCP), a regulator of complement activation. Immunogenetics 33 (5-6): 335-344. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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