PI-16, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | PI-16, Human |
| Clone | REA699 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | APC-Vio 770 conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | PI-16 Antibody, anti-human, APC-Vio® 770, REAfinity™. Clone REA699 recognizes the human peptidase inhibitor 16 (PI-16) antigen, also known as CRISP-9 or PSP94-binding protein. PI-16 belongs to the Activity cysteine-rich secretory protein (CRISP) family and is expressed in prostate, testis, ovary, and intestine. It is reported to be an independent prognostic marker for prostate cancer. Additionally, PI-16 is over-expressed by CD4+/CD25+ Treg cells, so it identifies a novel distinct subset of functional memory Treg cells, that are able to migrate to sites of inflammation and regulate the pro-inflammatory response. | Additional information: Clone REA699 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | Peptidase inhibitor 16, CRISP-9, PSP94-binding protein |
| Gene, Accession # | Gene ID: 221476 |
| Catalog # | 130-129-855 |
| Price | $166 |
| Order / More Info | PI-16, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Reeves, J. R. et al. (2005) Identification, purification and characterization of a novel human blood protein with binding affinity for prostate secretory protein of 94 amino acids. Biochem. J. 385 (1): 105-114. | Nicholson, I. C. et al. (2012) PI16 is expressed by a subset of human memory Treg with enhanced migration to CCL17 and CCL20. Cell. Immunol. 275 (1-2): 12-18. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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