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Antigenic Specificity | CD163, Human |
Clone | REA1309 |
Host Species | Recombinant Human |
Reactive Species | human |
Isotype | IgG1 |
Format | phycoerythrin (PE) conjugate |
Size | 200 µL |
Concentration | 1:50 |
Applications | Mass cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD163 Antibody, anti-human, PE, REAfinity™. Clone REA1309 recognizes the human CD163 antigen, a single-chain transmembrane protein also known as hemoglobin scavenger receptor or M130. It is expressed by mature tissue macrophages and peripheral blood monocytes. The expression of CD163 is up-regulated in vitro and in vivo by anti-inflammatory mediators such as IL-10 and (gluco)corticosteroid and is shed to blood upon inflammatory activation of macrophages. CD163 functions as a high affinity scavenger receptor for the complex of haemoglobin and haptoglobin. Depending on the ligand, crosslinking of CD163 initiates signal transduction leading to the production of proinflammatory cytokines Il-1β, IL-6, and GM-CSF or the anti-inflammatory cytokine IL-10. | Additional Information: Clone REA1309 displays negligible binding to Fc receptors. | |
Immunogen | n/a |
Other Names | M130 |
Gene, Accession # | Gene ID: 9332 |
Catalog # | 130-127-908 |
Price | $365 |
Order / More Info | CD163, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | n/a |