CD178, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD178, Human |
| Clone | REA1056 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD178 Antibody, anti-human, APC, REAfinity™. Clone REA1056 recognizes the CD178 antigen, a type II transmembrane glycoprotein also known as Fas ligand or CD95L. It is expressed on activated lymphocytes, e.g., T cells, NK cells, monocytes, or granulocytes, as well as at immune-privileged sites, e.g., cornea or testis. CD178 can trigger apoptosis through trimerization of the Fas receptor CD95. Thereby, CD178 and CD95 play a key role in the regulation of the immune system. Cleavage of membrane-bound CD178 from the cell surface via matrix metalloproteinases (such as MMP-7) generates soluble CD178 molecules. | Additional information: Clone REA1056 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | FASLG, ALPS1B, APT1LG1, APTL, CD95L, FasL, TNFSF6 |
| Gene, Accession # | Gene ID: 356 |
| Catalog # | 130-118-088 |
| Price | $325 |
| Order / More Info | CD178, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Suda, T. et al. (1993) Molecular cloning and expression of human Fas ligand. Cell 75: 1169-1178. | Kayagaki, N. et al. (1995) Metalloproteinase-mediated release of human Fas ligand. J. Exp. Med. 182: 1777-1783. | Janssen, O. et al. (2003) CD95 ligand - death factor and costimulatory molecule? Cell Death Differ. 10: 1215-1225. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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