FoxA2, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | FoxA2, Human |
| Clone | REA506 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | Vio B515 conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | FoxA2 Antibody, anti-human, Vio® B515, REAfinity™. Clone REA506 recognizes the human forkhead box A2 (FoxA2) antigen, a transcription factor which is also known as hepatocyte nuclear factor 3β (HNF-3β). FoxA2 is involved in embryonic development, establishment of tissue-specific gene expression, and regulation of gene expression in differentiated tissues. It is thought to act as a pioneer factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. In embryonic development, FoxA2 is required for notochord formation. It is involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas, and lungs. FoxA2 is also involved in glucose homeostasis. It regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. | Additional information: Clone REA506 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | HNF3B, HNF-3B, TCF-3B, TCF-3B, HNF-3β |
| Gene, Accession # | Gene ID: 3170 |
| Catalog # | 130-129-247 |
| Price | $158 |
| Order / More Info | FoxA2, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Li, Z. et al. (2012) Foxa2 and H2A.Z mediate nucleosome depletion during embryonic stem cell differentiation. Cell 151 (7): 1608-1616. | Yi, S. H. et al. (2014) Foxa2 acts as a co-activator potentiating expression of the Nurr1-induced DA phenotype via epigenetic regulation. Development 141 (4): 761-772. | Heddad Masson, M. et al. (2014) Foxa1 and Foxa2 regulate α-cell differentiation, glucagon biosynthesis, and secretion. Endocrinology 155 (10): 3781-3792. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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