β-Catenin, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | β-Catenin, Human |
| Clone | REAL641 |
| Host Species | Recombinant Human |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | fluorescein (FITC) conjugate |
| Size | 200 µL |
| Concentration | n/a |
| Applications | MICS (MACSima Imaging Cyclic Staining), Immunohistochemistry, Immunofluorescence |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | β-Catenin Antibody, anti-human, FITC, REAdye_lease™. Clone REAL641 is an antibody fragment derived from the full β-Catenin antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity. | Clone REAL641 recognizes the human β-Catenin antigen, a 92 kDa dual function protein regulating the coordination of cell-cell adhesion and gene transcription. β-Catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. As a component of adherens junctions, β-catenin binds cadherins, Tcf family transcription factors, and the tumor suppressor APC. Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer, malignant breast tumors, ovarian and endometrial cancer. | For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675). |
| Immunogen | n/a |
| Other Names | CTNNB1, CTNB1, Beta-catenin, Catnb |
| Gene, Accession # | n/a |
| Catalog # | 130-123-078 |
| Price | $385 |
| Order / More Info | β-Catenin, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Butz, S. et al. (1992) Plakoglobin and beta-catenin: distinct but closely related. Science 257 (5073): 1142-1144. | Clevers, H. et al. (2012) Wnt/β-catenin signaling and disease. Cell 149 (6): 1192-1205. | Yu, W. et al. (2017) β-Catenin Cooperates with CREB Binding Protein to Promote the Growth of Tumor Cells. Cell. Physiol. Biochem. 44 (2): 467-478. | MacDonald, B. T. et al. (2009) Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev. Cell 17 (1): 9-26. | Shang, S. et al. (2017) The regulation of β-catenin activity and function in cancer: therapeutic opportunities. Oncotarget. 8 (20): 33972-33989. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
Profile of MILTENYI BIOTEC B.V. & Co. KG