BMI-1, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | BMI-1, Human |
| Clone | REA438 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | Vio Bright V423 conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | BMI-1 Antibody, anti-human, Vio® Bright V423, REAfinity™. Clone REA438 recognizes the human B lymphoma Mo-MLV insertion region 1 homolog (BMI-1) antigen, which is also known as polycomb group RING finger protein 4 (PCGF4). BMI-1 is a member of the polycomb group of transcription repressors that was initially identified as an oncogene cooperating with c-myc in a murine model of lymphoma. Both, hematopoietic stem cells (HSCs) and neuronal stem cells, express high levels of BMI-1. It has been shown that BMI-1 is necessary for efficient self-renewing cell divisions of adult HSCs as well as adult peripheral and central nervous system neural stem cells, but that it is less critical for the generation of differentiated progeny. BMI-1 causes neoplastic proliferation when overexpressed in lymphocytes. | Additional information: Clone REA438 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | BMI1, FLVI2/BMI1, PCGF4, RNF51, flvi-2/bmi-1 |
| Gene, Accession # | Gene ID: 648 |
| Catalog # | 130-130-903 |
| Price | $500 |
| Order / More Info | BMI-1, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Park, I. K. et al. (2004) Bmi1, stem cells, and senescence regulation. J. Clin. Invest. 113 (2): 175-179. | Park, I. K. et al. (2003) Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature 423 (6937): 302-305. | Liu, S. et al. (2006) Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Res. 66 (12): 6063-6071. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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