CD64, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD64, Mouse |
| Clone | REA286 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | PE-Vio 770 conjugate |
| Size | 30 µg in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD64 Antibody, anti-mouse, PE-Vio® 770, REAfinity™. Clone REA286 recognizes the CD64 antigen, a 72 kDa integral membrane glycoprotein also known as high affinity immunoglobulin gamma Fc receptor I (FcγRI). Structurally CD64 is composed of a signal peptide that allows its transport to the surface of a cell, three extracellular immunoglobulin domains of the C2-type that it uses to bind antibody, a hydrophobic transmembrane domain, and a short cytoplasmic tail. CD64 is constitutively expressed on macrophages, monocytes, dendritic cells, and mast cells. Treatment with cytokines like IFN-γ and G-CSF induces CD64 upregulation. CD64 binds monomeric IgG-type antibodies with high affinity and mediates endocytosis, phagocytosis, antibody-dependent cellular toxicity, cytokine release, and superoxide generation. | Additional information: Clone REA286 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | FCGR1, FcgammaRI, IGGHAFC, FcR I, FcγRI |
| Gene, Accession # | Gene ID: 14129 |
| Catalog # | 130-119-659 |
| Price | $167 |
| Order / More Info | CD64, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Tan, P. S. et al. (2003) Unique monoclonal antibodies define expression of FcgRI on macrophages and mast cell lines and demonstrate heterogeneity among subcutaneous and other dendritic cells. J Immunol 170: 2549-2556. | Ioan-Facsinay, A. et al. (2002) FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection. Immunity 16 (3): 391-402. | Nimmerjahn, F. et al. (2006) Fcgamma receptors: old friends and new family members. Immunity 24 (1): 19-28. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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