STAT1 pY701, Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | STAT1 pY701, Human/Mouse |
| Clone | REA345 |
| Host Species | Recombinant Human |
| Reactive Species | human, mouse |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | STAT1 pY701 Antibody, anti-human/mouse, APC, REAfinity™. Clone REA345 recognizes the signal transducer and activator of transcription 1 (STAT1) antigen phosphorylated at tyrosine 701 (pY701). STAT1 expression is found ubiquitously. It is involved in upregulating genes due to a signal by either type I, type II, or type III interferons. In response to interferon γ (IFN-γ) stimulation, the STAT1 subunits become tyrosine-phosphorylated at pY701, and the complex is translocated to the nucleus. STAT1 forms homodimers or heterodimers with STAT3 that bind to the IFN-γ activated sequence promoter element. In response to either IFN-α or IFN-β stimulation, STAT1 forms a heterodimer with STAT2 that can bind the interferon stimulated response promoter element. In either case, binding of the promoter element leads to an increased expression of interferon stimulated genes. | Additional information: Clone REA345 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91 |
| Gene, Accession # | Gene ID: 6772 |
| Catalog # | 130-120-317 |
| Price | $136 |
| Order / More Info | STAT1 pY701, Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Gimeno, R. et al. (1996) STAT1 implication in the immune response to superantigens in vivo. J Immunol 156: 1378-1386. | Sikorski, K. et al. (2011) STAT1-mediated signal integration between IFNγ and LPS leads to increased EC and SMC activation and monocyte adhesion. Am. J. Physiol., Cell Physiol. 300: C1337-C1344. | Mowen, K. et al. (1998) Role of the STAT1-SH2 domain and STAT2 in the activation and nuclear translocation of STAT1. J. Biol. Chem. 273: 30073-30076. | ten Hoeve, J. et al. (2002) Identification of a nuclear Stat1 protein tyrosine phosphatase. Mol. Cell. Biol. 16: 5662-5668. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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