CD106 (VCAM-1), Rat Antibody from MILTENYI BIOTEC B.V. & Co. KG

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Antigenic SpecificityCD106 (VCAM-1), Rat
CloneMR106
Host SpeciesMouse
Reactive Speciesrat
IsotypeIgG1κ
Formatbiotin conjugate
Size9 µg in 300 µL
Concentration1:10
ApplicationsFlow cytometry
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DescriptionCD106 (VCAM-1) Antibody, anti-rat, Biotin. Clone MR106 recognizes the CD106 antigen, a 110 kDa transmembrane protein also known as vascular cell adhesion protein 1 (VCAM-1). CD106 is expressed on bone marrow stromal cells, myeloid cells, and dendritic cells, but not on peripheral leukocytes. Expression on endothelial cells is upregulated upon inflammatory cytokine stimulation. CD106 is an endothelial ligand for the very late antigen-4 (VLA-4 or α4β1) of the β1 subfamily of integrins, and for integrin α4β7. It mediates the adhesion of lymphocytes, monocytes, eosinophils, and basophils to vascular endothelium. CD106 also functions in leukocyte-endothelial cell signal transduction, and it may play a role in the development of atherosclerosis and rheumatoid arthritis.
Immunogenn/a
Other NamesVCAM1, VCAM1B
Gene, Accession #Gene ID: 25361
Catalog #130-103-771
Price$31
Order / More InfoCD106 (VCAM-1), Rat Antibody from MILTENYI BIOTEC B.V. & Co. KG
Product Specific ReferencesHession, C. et al. (1992) Cloning of murine and rat vascular cell adhesion molecule-1. Biochem. Biophys. Res. Commun. 183 (1): 163-169. | Barreiro, O. et al. (2002) Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes. J. Cell Biol. 157 (7): 1233-1245. | Gao, Z. et al. (2012) Vascular endothelial growth factor participates in modulating the C6 glioma-induced migration of rat bone marrow-derived mesenchymal stem cells and upregulates their vascular cell adhesion molecule-1 expression. Exp Ther Med. 4 (6): 993-998.
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-Straße 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197

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