CD106 (VCAM-1), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD106 (VCAM-1), Mouse |
| Clone | REA971 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | biotin conjugate |
| Size | 30 µg in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD106 (VCAM-1) Antibody, anti-mouse, Biotin, REAfinity™. Clone REA971 recognizes the mouse CD106 antigen, a 110 kDa single-chain type I glycoprotein, also known as vascular cell adhesion protein 1 (VCAM-1). CD106 is expressed on bone marrow cells, stromal cells, and inflamed vascular endothelium as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue. Upregulation of CD106 in endothelial cells by inflammatory stimuli and cytokines occurs as a result of increased gene transcription. Primarily, CD106 is an endothelial ligand for very late antigen-4 (VLA-4) or integrin α-4/β-7 and mediates both adhesion and signal transduction. The interactions play a pathophysiologic role in leukocyte adhesion, transmigration, and co-stimulation of T cell proliferation. | Additional information: Clone REA971 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | VCAM1, INCAM-100 |
| Gene, Accession # | Gene ID: 22329 |
| Catalog # | 130-116-321 |
| Price | $64 |
| Order / More Info | CD106 (VCAM-1), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Kumar, A. G. et al. (1994) Murine VCAM-1. Molecular cloning, mapping, and analysis of a truncated form J Immunol 153 (9): 4088-4098. | Ou, R. et al. (2008) Regulation of immune response and inflammatory reactions against viral infection by VCAM-1. J. Virol. 82 (6): 2952-2965. | Kokovay, E. et al. (2012) VCAM1 is essential to maintain the structure of the SVZ niche and acts as an environmental sensor to regulate SVZ lineage progression. Cell Stem Cell 11 (2): 220-230. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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