IFN-α, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | IFN-α, Human |
| Clone | REA1013 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | Vio R667 conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | IFN-α Antibody, anti-human, Vio® R667, REAfinity™. Type I interferons (IFNs), including IFN-α, are a family of cytokines that exert pleiotropic functions in the immune system. Besides its potent antiviral activity, IFN-α exerts a variety of immunomodulatory effects, including positive and negative regulation of its own production, regulation of IL-12 and IFN-γ production, promotion of natural killer (NK) cell cytotoxicity, activation and maturation of dendritic cells, and the promotion of B cell development towards plasma cells. IFN-α is expressed predominantly by CD123+CD11c-CD303 (BDCA2)+ plasmacytoid dendritic cells (pDCs). Clone REA1013 recognizes the majority of the IFN-α subtypes, including IFN-α2b. | Additional information: Clone REA1013 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | IFNA1 |
| Gene, Accession # | Gene ID: 3439, 3444, 3443, 3449, 3442, 3448, 3446, 3441, 3452, 3447, 3445, 3451, 3440 |
| Catalog # | 130-116-996 |
| Price | $189 |
| Order / More Info | IFN-α, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Ronnblom, L. and Alm, G. V. (2001) An etiopathogenic role for the type I IFN system in SLE. Trends Immunol. 22: 427-431. | Bave, U. et al. (2003) Fc gamma RIIa is expressed on natural IFN-alpha-producing cells (plasmacytoid dendritic cells) and is required for the IFN-alpha production induced by apoptotic cells combined with lupus IgG. J Immunol 171 (6): 3296-3302. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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