TNF-α, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | TNF-α, Human |
| Clone | REA656 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | Vio B515 conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Intracellular flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | TNF-α Antibody, anti-human, Vio® B515, REAfinity™. Clone REA656 recognizes the human tumor necrosis factor alpha (TNF-α) antigen, which is a cytokine involved in inflammatory immune responses. TNF-α has different functions, it plays an important role in the regulation of immune cells and is a potent pyrogen causing fever and apoptotic cell death. Furthermore, the TNF intracellular domain form is able to induce interleukin 12 (IL-12) production in dendritic cells. TNF-α is secreted by activated CD4+ T cells, monocytes, macrophages, natural killer (NK) cells, mast cells, eosinophils, and neutrophils. | Additional information: Clone REA656 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | Tumor necrosis factor, Cachectin, TNF-alpha, TNF-a, DIF-alpha, TNFa, TNFSF2 |
| Gene, Accession # | Gene ID: 7124 |
| Catalog # | 130-129-189 |
| Price | $385 |
| Order / More Info | TNF-α, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Friedmann, E. et al. (2006) SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production. Nat. Cell Biol. 8 (8): 843-848. | Nedwin, G. E. et al. (1985) Human lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization. Nucleic Acids Res. 13 (17): 6361-6373. | Nedospasov, S. A. et al. (1985) Tandem arrangement of genes coding for tumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta) in the human genome. Cold Spring Harb. Symp. Quant. Biol. 51 (1): 611-624. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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