CD191 (CCR1), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG

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Antigenic SpecificityCD191 (CCR1), Human
CloneREA158
Host SpeciesRecombinant Human
Reactive Specieshuman
IsotypeIgG1
Formatphycoerythrin (PE) conjugate
Size30 tests in 300 µL
Concentration1:11
ApplicationsFlow cytometry
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DescriptionCD191 (CCR1) Antibody, anti-human, PE, REAfinity™. Clone REA158 recognizes CCR1, a chemokine receptor that binds to CC subgroup of chemokines as ligands. Chemokines are small chemoattractant protein molcules and are subdivided into families CC, CXC, or CX3C.Chemokines exert their action via binding to corresponding chemokine receptors, which are G protein-coupled receptors and share several structural features. CCR1 binds chemokines auch as CCL3, CCL5, CCL7, and CCL14 as ligands. Expression of CCR1 is found on macrophages, natural killer cells, T cells, DC, monocytes, basophils, and eosinophils, where regulated CCR1 expression can be achieved by molecules such as IL2 and TGF-β2. CCR1-ligand interaction plays role in leukocyte migration, cell differentiation/activation and immune response. | Additional information: Clone REA158 displays negligible binding to Fc receptors. ?????
Immunogenn/a
Other NamesCCR1, CKR-1, CMKBR1, HM145, MIP1aR, SCYAR1
Gene, Accession #Gene ID: 1230
Catalog #130-100-368
Price$121
Order / More InfoCD191 (CCR1), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
Product Specific ReferencesNess, T. L. et al. (2004) CCR1 and CC chemokine ligand 5 interactions exacerbate innate immune responses during sepsis. J Immunol 173: 6938-6948. | Manzo, A. et al. (2003) Role of chemokines and chemokine receptors in regulating specific leukocyte trafficking in the immune/inflammatory response. Clin. Exp. Rheumatol. 21 (4): 501-508.
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-Straße 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197

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