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Antigenic Specificity | GARP (LRRC32), Human |
Clone | REA166 |
Host Species | Recombinant Human |
Reactive Species | human |
Isotype | IgG1 |
Format | biotin conjugate |
Size | 100 tests in 1 mL |
Concentration | 1:11 |
Applications | Mass cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | GARP (LRRC32) Antibody, anti-human, Biotin, REAfinity™. Clone REA166 recognizes the human glycoprotein A repetitions predominant (GARP) antigen, a 80 kDa type I membrane glycoprotein which belongs to the family of leucine rich repeat proteins. Expression of GARP protein is found on megakaryocytes, platelets, and activated regulatory T cells (Treg cells). GARP has been found to be associated with latency associated peptide (LAP), the prodomain responsible for conferring latency to non-active TGF-β. Thus, GARP as a latent TGF-β-binding protein (LTBP) regulates the surface expression of TGF-β and serves as a carrier of LAP, at the cell surface, to immune response active sites, where TGF-β is eventually activated and released to exert further physiological functions such as differentiation of regulatory T cells. | Additional information: Clone REA166 displays negligible binding to Fc receptors. | |
Immunogen | n/a |
Other Names | LRRC32, D11S833E, Glycoprotein A repetitions predominant (GARP), LRRC32 |
Gene, Accession # | Gene ID: 2615 |
Catalog # | 130-104-313 |
Price | $264 |
Order / More Info | GARP (LRRC32), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Zhou, A. X. et al. (2013) GARP-TGF-β complexes negatively regulate regulatory T cell development and maintenance of peripheral CD4+ T cells in vivo. J Immunol 190 (10): 5057-5064. | Tran, D. Q. et al. (2009) GARP (LRRC32) is essential for the surface expression of latent TGF-β on platelets and activated FOXP3+ regulatory T cells. Proc. Natl. Acad. Sci. U.S.A. 106: 13445-13450. | Ollendorff, V. et al. (1994) The GARP gene encodes a new member of the family of leucine-rich repeat-containing proteins. Cell Growth Differ. 5: 213-219. |