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Antigenic Specificity | CD268, Mouse |
Clone | REA1217 |
Host Species | Recombinant Human |
Reactive Species | mouse |
Isotype | IgG1 |
Format | PE-Vio 770 conjugate |
Size | 30 µg in 200 µL |
Concentration | 1:50 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD268 Antibody, anti-mouse, PE-Vio® 770, REAfinity™. Clone REA1217 recognizes the CD268 protein, also known as B cell activation factor receptor (BAFF-R), which is a type III transmembrane TNF receptor family member. CD268 is expressed at high levels on resting B cells, at lower levels on activated B cells, and on a small subset of activated/memory T cells. BAFF, also known as BLys, mediates costimulatory responses in peripheral B and T cells. BAFF is a key regulator for B cell differentiation as well as survival and activation of peripheral B cell populations. Accordingly, CD268 appears to be particularly involved in the regulation of normal B cell survival and maturation, but also in the pathophysiology of aggressive B cell malignancies and autoimmune diseases. | Additional information: Clone REA1217 displays negligible binding to Fc receptors. |
Immunogen | n/a |
Other Names | BAFF-R, BLyS receptor 3, TNFRSF13c, BAFFR, Bcmd, BR3 |
Gene, Accession # | Gene ID: 72049 |
Catalog # | 130-123-436 |
Price | $162 |
Order / More Info | CD268, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Thompson, J. S. et al. (2001) BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF. Science 293 (5537): 2108-2111. | Ng, L. G. et al. (2006) BAFF costimulation of Toll-like receptor-activated B-1 cells. Eur. J. Immunol. 36 (7): 1837-1846. |