ZAP70 pY292, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | ZAP70 pY292, Human |
| Clone | REA411 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | phycoerythrin (PE) conjugate |
| Size | 100 tests in 1 mL |
| Concentration | 1:11 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | ZAP70 pY292 Antibody, anti-human, PE, REAfinity™. Clone REA411 recognizes the human Zeta-chain-associated protein kinase 70 (ZAP70) antigen phosphorylated at tyrosine 292 (pY292). ZAP70 plays an essential role in regulation of the adaptive immune response. It is normally expressed near the surface membrane of T cells and natural killer cells. ZAP70 associates with the ζ subunit of the T cell antigen receptor, and plays a critical role in T cell-signaling. It regulates both T cell-activation switch on and switch off by modulating TCR expression at the T cell surface. During thymocyte development, ZAP70 promotes survival and cell-cycle progression of developing thymocytes before positive selection. Additionally, the ZAP70-dependent signaling pathway may also contribute to primary B cells formation and activation through the B cell receptor. Recruitment and activation of ZAP70 are transient and are terminated by phosphorylation of negative regulatory tyrosine residues and dephosphorylation of positively acting sites. In vivo analyses suggest that phosphorylation of residue Y292 plays a role in attenuation of TCR signaling. | Additional information: Clone REA411 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | SRK, STCD, STD, TZK, ZAP-70 |
| Gene, Accession # | Gene ID: 7535 |
| Catalog # | 130-106-945 |
| Price | $310 |
| Order / More Info | ZAP70 pY292, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Arpaia, E. et al. (1994) Defective T cell receptor signaling and CD8+ thymic selection in humans lacking zap-70 kinase. Cell 76 (5): 947-958. | Chan, A. C. et al. (1992) ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain. Cell 71 (4): 649-662. | Bottini, N. et al. (2002) Activation of ZAP-70 through specific dephosphorylation at the inhibitory Tyr-292 by the low molecular weight phosphotyrosine phosphatase (LMPTP). J. Biol. Chem. 277 (27): 24220-24224. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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