CD43 Glycoform, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD43 Glycoform, Mouse |
| Clone | REA364 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | PerCP-Vio 700 conjugate |
| Size | 9 µg in 300 µL |
| Concentration | 1:10 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD43 Glycoform Antibody, anti-mouse, PerCP-Vio® 700, REAfinity™. Clone REA364 recognizes the activation-associated glycoform (130-kD glycoform) of the murine CD43 antigen, a cell-surface glycoprotein which is also known as sialophorin or leukosialin. CD43 is a heavily O-glycosylated protein which is expressed in a variety of hematopoietic lineage cells, including T lymphocytes. It has been reported to have two glycoforms, one with a molecular mass of 115 kD that is expressed on all T cells and one with a mass of 130 kD that is expressed only on activated T cells. Biochemical analysis showed that CD43 on resting T cells carries tetrasaccharides (115-kD glycoform), whereas activated T cells carry branched hexasaccharide core two O-glycans (130-kD glycoform). Expression of the 130-kD glycoform of CD43 on all T cells in transgenic mice shows a reduction in primary T-cell immune responses that is probably due to the antiadhesive function of this glycoform. | Additional information: Clone REA364 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | Spn, B-cell differentiation antigen LP-3, GALGP, Ly-48, Sialophorin, CD43 |
| Gene, Accession # | Gene ID: 20737 |
| Catalog # | 130-105-383 |
| Price | $53 |
| Order / More Info | CD43 Glycoform, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Carlow, D. A. et al. (1999) A novel CD8 T cell-restricted CD45RB epitope shared by CD43 is differentially affected by glycosylation. J Immunol 163 (3): 1441-1448. | van den Berg, T. K. et al. (2001) Cutting Edge: CD43 functions as a T cell counterreceptor for the macrophage adhesion receptor Sialoadhesin (Siglec-1). J Immunol 166: 3637- 3640. | Alcaide, P. et al. (2007) The 130-kDa glycoform of CD43 functions as an E-selectin ligand for activated T?1 cells in vitro and in delayed-type hypersensitivity reactions in vivo. J. Invest. Dermatol. 127 (8): 1964-1972. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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