CD126 (IL-6Rα), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD126 (IL-6Rα), Human |
| Clone | REA291 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | PE-Vio 770 conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD126 (IL-6Rα) Antibody, anti-human, PE-Vio® 770, REAfinity™. Clone REA291 recognizes the CD126 antigen, a type I cytokine receptor also known as interleukin 6 receptor subunit alpha (IL-6Rα) or membrane glycoprotein 80 (gp80). CD126 associates with the IL-6 receptor β chain (CD130 or gp130) resulting in the formation of a functional high affinity IL-6 receptor (IL-6R) complex. It is also shared by many other receptors like leukemia inhibitory factor (LIF), ciliary neurotropic factor (CNTF), oncostatin M (OSM), IL-11, and cardiotropin 1 (CT-1). CD126 (IL-6Rα) is highly expressed on activated and EBV-transformed B cells, plasma cells, and myeloma cells. Lower expression levels are detected on T cells, monocytes, granulocytes, hepatocytes, epithelial cells, fibroblasts, and neural cells. Interleukin 6 (IL-6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. IL-6 binding to the receptor complex results in the stimulation of B and T cells, and hematopoietic precursor proliferation and differentiation. A soluble form of CD126 also exists in human serum. Dysregulated production of IL-6 and the IL-6R are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases, and prostate cancer. | Additional information: Clone REA291 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | Il6r, IL-6R-1, IL-6RA, IL6Q, IL6RA, IL6RQ, gp80 |
| Gene, Accession # | Gene ID: 3570 |
| Catalog # | 130-127-923 |
| Price | $156 |
| Order / More Info | CD126 (IL-6Rα), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Yamasaki, K. et al. (1998) Cloning and expression of the human interleukin-6 (BSF-2/IFN β2) receptor. Science 241 (4867): 825-828. | Schooltink, H. et al. (1991) Structural and functional studies on the human hepatic interleukin-6 receptor. Molecular cloning and overexpression in HepG2 cells. Biochem. J. 277 (3): 659-664. | Taga, T. et al. (1989) Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130. Cell 58 (3): 573-581. | Schloder, J. et al. (2017) Dimethyl fumarate therapy significantly improves the responsiveness of T cells in Multiple sclerosis patients for immunoregulation by regulatory T cells. Int J Mol Sci 18: E271. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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