CD152, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG

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Antigenic SpecificityCD152, Mouse
CloneUC10-4B9
Host SpeciesHamster
Reactive Speciesmouse
IsotypeIgG1
Formatbiotin conjugate
Size30 µg in 1 mL
Concentration1:10
ApplicationsIntracellular flow cytometry
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DescriptionCD152 Antibody, anti-mouse, Biotin. The monoclonal antibody UC10-4B9 reacts with CD152, also known as cytotoxic T lymphocyte antigen-4 (CTLA-4), which is a 33 kDa member of the immunoglobin superfamily and is expressed on activated T cells at a low level. CTLA-4 and CD28 have similarities concerning B7 family counter-receptors. While CD28 delivers a costimulary signal in T cell activation, CD152 restricts the progression of T cells to an activated state by inhibiting interleukin 2 (IL-2) secretion and cellular proliferation. A large proportion of CTLA-4 is intracellular localized. For a complete detection it may be necessary to assess intracellular staining in addition to surface expression of CD152.
Immunogenn/a
Other NamesCTLA4, CTLA-4, Ly-56
Gene, Accession #Gene ID: 12477
Catalog #130-101-924
Price$57
Order / More InfoCD152, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
Product Specific ReferencesWalunas, T. L. et al. (1994) CTLA-4 can function as a negative regulator of T cell activation. Immunity 1 (5): 405-413. | Krummel, M. F. and Allison, J. P. (1995) CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J. Exp. Med. 182 (2): 459-465. | June, C. H. et al. (1994) The B7 and CD28 receptor families. Immunol. Today 15 (7): 321-331.
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-Straße 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197

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