Edit |   |
---|---|
Antigenic Specificity | CD178, Human |
Clone | REA1056 |
Host Species | Recombinant Human |
Reactive Species | human |
Isotype | IgG1 |
Format | PE-Vio 615 conjugate |
Size | 30 tests in 60 µL |
Concentration | 1:50 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD178 Antibody, anti-human, PE-Vio® 615, REAfinity™. Clone REA1056 recognizes the CD178 antigen, a type II transmembrane glycoprotein also known as Fas ligand or CD95L. It is expressed on activated lymphocytes, e.g., T cells, NK cells, monocytes, or granulocytes, as well as at immune-privileged sites, e.g., cornea or testis. CD178 can trigger apoptosis through trimerization of the Fas receptor CD95. Thereby, CD178 and CD95 play a key role in the regulation of the immune system. Cleavage of membrane-bound CD178 from the cell surface via matrix metalloproteinases (such as MMP-7) generates soluble CD178 molecules. | Additional information: Clone REA1056 displays negligible binding to Fc receptors. |
Immunogen | n/a |
Other Names | FASLG, ALPS1B, APT1LG1, APTL, CD95L, FasL, TNFSF6 |
Gene, Accession # | Gene ID: 356 |
Catalog # | 130-118-162 |
Price | $162 |
Order / More Info | CD178, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Suda, T. et al. (1993) Molecular cloning and expression of human Fas ligand. Cell 75: 1169-1178. | Kayagaki, N. et al. (1995) Metalloproteinase-mediated release of human Fas ligand. J. Exp. Med. 182: 1777-1783. | Janssen, O. et al. (2003) CD95 ligand - death factor and costimulatory molecule? Cell Death Differ. 10: 1215-1225. |