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Antigenic Specificity | Jak1, Human/Mouse/Rat |
Clone | REA700 |
Host Species | Recombinant Human |
Reactive Species | human, mouse, rat |
Isotype | IgG1 |
Format | Vio B515 conjugate |
Size | 30 tests in 60 µL |
Concentration | 1:50 |
Applications | Intracellular flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Jak1 Antibody, anti-human/mouse/rat, Vio® B515, REAfinity™. Clone REA700 recognizes the human, mouse, and rat Jak1 antigen, also known as tyrosine-protein kinase JAK1 or janus kinase 1. Jak1 is a widely expressed membrane-associated phosphoprotein characterized by the presence of a second phosphotransferase-related domain immediately N terminal to the PTK domain. Jak1 is involved in the IFN-α/β/γ signal pathway and activates transcription factors of the STAT family by phosphorylating critical tyrosine regulatory sites. | Additional information: Clone REA700 displays negligible binding to Fc receptors |
Immunogen | n/a |
Other Names | Tyrosine-protein kinase JAK1, Janus kinase 1, JAK-1 |
Gene, Accession # | Gene ID: 3716, 16451, 84598 |
Catalog # | 130-130-987 |
Price | $158 |
Order / More Info | Jak1, Human/Mouse/Rat Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Wilks, A. F. et al. (1991) Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase. Mol. Cell. Biol. 11 (4): 2057-2065. | Williams, N. K. et al. (2009) Dissecting specificity in the Janus kinases: the structures of JAK-specific inhibitors complexed to the JAK1 and JAK2 protein tyrosine kinase Domains. J. Mol. Biol. 387 (1): 219-232. |