CD142, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD142, Human |
| Clone | REA949 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | Vio Bright V423 conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD142 Antibody, anti-human, Vio® Bright V423, REAfinity™. Clone REA949 recognizes the human CD142 antigen, a 45 kDa type I transmembrane glycoprotein also known as tissue factor (TF). It functions as the high-affinity receptor for the coagulation factor VII and enables cells to initiate the blood coagulation cascades. It is reported, that the tissue factor exists in a membrane-bound and in a soluble form. It is expressed on activated endothelial cells and on monocytes, macrophages, and platelets, which are stimulated with inflammatory mediators such as LPS or tumor necrosis factor alpha (TNFα). CD142 is also present on some tumor cells such as lung, breast, pancreatic, and colon, as well as on non-immune-tissues. | Additional information: Clone REA949 displays negligible binding to Fc receptors |
| Immunogen | n/a |
| Other Names | Tissue Factor, Coagulation factor III, Thromboplastin, TF |
| Gene, Accession # | Gene ID: 2152 |
| Catalog # | 130-131-085 |
| Price | $500 |
| Order / More Info | CD142, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Carson, S. D. et al. (1994) Fibroblast tissue factor: calcium and ionophore induce shape changes, release of membrane vesicles, and redistribution of tissue factor antigen in addition to increased procoagulant activity. Blood 84: 526-534. | Golino, P. et al. (2002) The inhibitors of the tissue factor: factor VII pathway. Thromb. Res. 106 (3): V257-V265. | Bogdanov, V. Y. et al. (2003) Alternatively spliced human tissue factor: a circulating, soluble, thrombogenic protein. Nat Med 9: 458-462. | Butenas, S. et al. (2008) Tissue factor activity and function in blood coagulation. Thromb. Res. 122: S42-S46. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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