Edit |   |
---|---|
Antigenic Specificity | CD178, Mouse |
Clone | MFL3 |
Host Species | Hamster |
Reactive Species | mouse |
Isotype | IgG |
Format | biotin conjugate |
Size | 9 µg in 300 µL |
Concentration | 1:10 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD178 Antibody, anti-mouse, Biotin. The monoclonal antibody MFL3 recognizes the type II transmembrane glycoprotein mouse CD178, also known as Fas Ligand (FasL) or CD95 Ligand (CD95L), which is a 40 kDa member of the TNF cytokine family expressed on activated lymphocytes such as T cells, NK cells, or monocytes as well as in immune-privilaged sites, e.g cornea or testis. CD178 can trigger apoptosis through trimerization of the Fas receptor CD95. Thereby, CD178 and CD95 play a key role in the regulation of the immune system. Cleavage of membrane bound CD178 from the cell surface via matrix metalloproteinases (such as MMP-7) generates soluble CD178 molecules. | | |
Immunogen | n/a |
Other Names | FasL, APT1LG1, CD95L, TNFSF6, gld |
Gene, Accession # | n/a |
Catalog # | 130-102-055 |
Price | $30 |
Order / More Info | CD178, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Oyaizu, N. et al. (1997) Monocytes express Fas ligand upon CD4 cross-linking and induce CD4+ T cells apoptosis: a possible mechanism of bystander cell death in HIV infection. J Immunol 158: 2456 -2463. | Kayagaki, N. et al. (1997) Polymorphism of murine Fas ligand that affects the biological activity. Proc. Natl. Acad. Sci. U.S.A. 94: 3914 -3919. | Takahashi, T. et al. (1994) Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 76 (6): 969-976. | Janssen, O. et al. (2003) CD95 ligand - death factor and costimulatory molecule? Cell Death Differ. 10 (11): 1215-1225. |