CD140b pY857, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD140b pY857, Mouse |
| Clone | REA628 |
| Host Species | Recombinant Human |
| Reactive Species | mouse, human |
| Isotype | IgG1 |
| Format | phycoerythrin (PE) conjugate |
| Size | 30 µg in 1 mL |
| Concentration | 1:10 |
| Applications | Intracellular flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD140b pY857 Antibody, anti-mouse, PE, REAfinity™. Clone REA628 recognizes the mouse CD140b antigen phosphorylated at tyrosine 857 (pY857). CD140b is a single-pass type I membrane protein also known as platelet-derived growth factor receptor beta (PDGFR-beta). PDGFR is composed of PDGFRα (CD140a) and/or PDGFRβ (CD140b) molecules. CD140b is broadly expressed in embryonic tissue and in cells of mesodermal origin, in adult tissue as fibroblasts, smooth muscle cells, glial cells, and chondrocytes. It is a tyrosine-protein kinase and receptor dimerization and transphosphorylation at tyrosine residues activates the intracellular kinase activity. CD140b plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis, and migration. | Additional information: Clone REA628 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | PDGF-R-beta, PDGFR-beta, PDGFR-1, AI528809, Pdgfr |
| Gene, Accession # | Gene ID: 18596 |
| Catalog # | 130-109-745 |
| Price | $67 |
| Order / More Info | CD140b pY857, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Gao, B. B. et al. (2006) Angiotensin II stimulates phosphorylation of an ectodomain-truncated platelet-derived growth factor receptor-beta and its binding to class IA PI3K in vascular smooth muscle cells. Biochem. J. 397 (2): 337-344. | Fiaschi, T. et al. (2003) Down-regulation of platelet-derived growth factor receptor signaling during myogenesis. Cell. Mol. Life Sci. 60 (12): 2721-2735. | Getachew, R. et al. (2010) PDGF beta-receptor kinase activity and ERK1/2 mediate glycosaminoglycan elongation on biglycan and increases binding to LDL. Endocrinology 151 (9): 4356-4367. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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