p70 S6 Kinase, Human/Mouse/Rat Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | p70 S6 Kinase, Human/Mouse/Rat |
| Clone | REA843 |
| Host Species | Recombinant Human |
| Reactive Species | human, mouse, rat |
| Isotype | IgG1 |
| Format | phycoerythrin (PE) conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | p70 S6 Kinase Antibody, anti-human/mouse/rat, PE, REAfinity™. Clone REA843 recognizes the intracellular p70 S6 Kinase, also known as ribosomal protein S6 kinase beta-1. It is a serine/threonine kinase that is widely expressed in the cytosol and in the nucleus. It mediates cell cycle progression and is involved in the regulation of protein synthesis. The p70 S6 kinase is localized in cytosol and in the nucleus, after cytokine stimulation. TNF-receptor activation leads to activation of the p70 S6 kinase, which increases protein synthesis and cell proliferation. In addition, p70 S6 kinase is a major effector of mammalian target of rapamycin (mTOR) phosphorylation. | Additional information: Clone REA843 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | S6K-beta-1, S6K1, P70S6K1, p70-S6K 1 |
| Gene, Accession # | Gene ID: 6198, 72508, 83840 |
| Catalog # | 130-112-735 |
| Price | $315 |
| Order / More Info | p70 S6 Kinase, Human/Mouse/Rat Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Gout, I. et al. (1998) Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region. J. Biol. Chem. 273 (46): 30061-30064. | Fleckenstein, D. S. et al. (2003) Tumor necrosis factor receptor-associated factor (TRAF) 4 is a new binding partner for the p70S6 serine/threonine kinase. Leuk. Res. 27 (8): 687-694. | Holz, M. K. et al. (2005) Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase. J. Biol. Chem. 280 (28): 26089-26093. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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