CD158a (KIR2DL1), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD158a (KIR2DL1), Human |
| Clone | REA284 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | APC-Vio 770 conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD158a (KIR2DL1) Antibody, anti-human, APC-Vio® 770, REAfinity™. Clone REA284 recognizes human CD158a (KIR2DL1), but not KIR2DL2, 2DL3, 2DL4, 2DL5, 2DS1, 2DS2, 2DS4, 3DL1, 3DL2, or 3DS1. CD158a is 58 kDa protein, also known as KIR2DL1. CD158a is a member of the family of killer cell immunoglobulin-like receptors (KIRs) comprising transmembrane glycoproteins expressed on NK cells and a subset of T cells. Many groups of KIRs exist including KIR3DL1-3, KIR3DS1, KIR2DL1-5, and KIR2DS1-5. The isoforms have either a short (S) or long (L) cytoplasmic domain which transduce either an activating or inhibitory signal, respectively. The ligands of CD158a (KIR2DL1) are HLA-C molecules with Asn77 and Lys80, but not Ser77 and Asn80. | Additional information: Clone REA284 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | KIR2DL1, KIR-K64, KIR221, NKAT, NKAT-1, p58.1 |
| Gene, Accession # | Gene ID: 3802 |
| Catalog # | 130-118-345 |
| Price | $360 |
| Order / More Info | CD158a (KIR2DL1), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Vales-Gomez, M. et al. (1998) Kinetics of interaction of HLA-C ligands with natural killer cell inhibitory receptors. Immunity 9 (3): 337-333. | Wagtmann, N. et al. (1995) Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains. Immunity 2 (5): 439-449. | Fan, Q. R. et al. (2001) Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex. Nat Immunol 2 (5): 452-460. | Colonna, M. et al. (1995) Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells. Science 268 (5209): 405-408. | Jackson, E. et al. (2017) HIV exposed seronegative (HESN) compared to HIV infected individuals have higher frequencies of telomeric killer immunoglobulin-like receptor (KIR) B motifs; contribution of KIR B motif encoded genes to NK cell responsiveness. PLoS One 12 (9): e0185160. | Chapel, A. et al. (2017) Peptide-specific engagement of the activating NK cell receptor KIR2DS1. Sci Rep 7 (1): 2414. | Lu, W. et al. (2016) Suppression of HIV replication by CD8+ regulatory T-cells in elite controllers. Front Immunol 7: 134. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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