CD79b, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD79b, Mouse |
| Clone | HM79-12 |
| Host Species | Hamster |
| Reactive Species | mouse |
| Isotype | IgG |
| Format | phycoerythrin (PE) conjugate |
| Size | 30 µg in 1 mL |
| Concentration | 1:10 |
| Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD79b Antibody, anti-mouse, PE. Clone HM79-12 recognizes the mouse CD79b antigen, a 35-40kD Single-pass type I membrane protein also known as B-cell antigen receptor complex-associated protein beta chain (Igβ chain). The heterodimeric CD79 molecule is composed of an α chain (CD79a) and a β chain (CD79b) and is associated with surface immunoglobulins to form the B cell receptor. The CD79a/CD79b heterodimer facilitates the differentiation of pre-B cells from pro-B cells, surface expression of surface Ig, signal transduction following antigen recognition and endocytosis of recognized antigens. Crosslinking of CD79b in vitro by monoclonal antibodies activates pre-B cells but blocks terminal differentiation of all plasma cell isotypes. It was shown that a combination of CD79α and CD79β monoclonal antibodies can effectively deplete B cells from peripheral blood, spleen, bone marrow, and lymph nodes in mice. | |
| Immunogen | n/a |
| Other Names | B29, Igbeta, Igb |
| Gene, Accession # | Gene ID: 15985 |
| Catalog # | 130-105-833 |
| Price | $71 |
| Order / More Info | CD79b, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Li, Y. et al. (2008) B cell depletion with anti-CD79 mAbs ameliorates autoimmune disease in MRL/lpr mice. J Immunol 181 (5): 2961-2972. | Lin, J. and Justement, L. B. (1992) The MB-1/B29 heterodimer couples the B cell antigen receptor to multiple src family protein tyrosine kinases. J Immunol 149: 1548-1555. | O'Neill, S. K. et al. (2011) Monophosphorylation of CD79a and CD79b ITAM motifs initiates a SHIP-1 phosphatase-mediated inhibitory signaling cascade required for B cell anergy. Immunity 35 (5): 746-756. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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