CD133/1, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG

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Antigenic SpecificityCD133/1, Human
CloneAC133
Host SpeciesMouse
Reactive Specieshuman
IsotypeIgG1κ
FormatPE-Vio 615 conjugate
Size30 tests in 60 µL
Concentration1:50
ApplicationsFlow cytometry
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DescriptionCD133/1 Antibody, anti-human, PE-Vio® 615. CD133, formerly known as AC133, recognizes epitope 1 of the CD133 antigen. It is a marker that is frequently found on multipotent progenitor cells, including immature hematopoietic stem and progenitor cells. In the hematopoietic system, CD133 is expressed on a small portion of CD34- cells as well as on a subset of CD34bright stem and progenitor cells in human fetal liver, bone marrow, cord blood, and peripheral blood. CD133 has also been found to be expressed on circulating endothelial progenitor cells, fetal neural stem cells, other tissue-specific stem cells, such as renal, prostate, and corneal stem cells, cancer stem cells from tumor tissues, as well as ES and iPS cell-derived cells.
Immunogenn/a
Other NamesPROM1, AC133, CORD12, MCDR2, MSTP061, PROML1, RP41, STGD4
Gene, Accession #Gene ID: 8842
Catalog #130-113-671
Price$162
Order / More InfoCD133/1, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
Product Specific ReferencesGiebel, B. et al. (2004) Segregation of lipid raft markers including CD133 in polarized human hematopoietic stem and progenitor cells. Blood 104 (8): 2332-2338. | Ingram, D. A. et al. (2004) Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood. Blood 104 (9): 2752-2760. | Miraglia, S. et al. (1997) A novel five-transmembrane hematopoietic stem cell antigen: isolation, characterization, and molecular cloning. Blood 90 (12): 5013-5021. | Wagner, W. et al. (2004) Molecular evidence for stem cell function of the slow-dividing fraction among human hematopoietic progenitor cells by genome-wide analysis. Blood 104 (3): 675-686. | Yin, A. H. et al. (1997) AC133, a novel marker for human hematopoietic stem and progenitor cells. Blood 90: 5002-5012. | Gallacher, L. et al. (2000) Isolation and characterization of human CD34-Lin- and CD34+Lin- hematopoietic stem cells using cell surface markers AC133 and CD7. Blood 95 (ARVO Annual Meeting Abstract): 2813-2820. | Gehling, U. M. et al. (2000) In vitro differentiation of endothelial cells from AC133-positive progenitor cells. Blood 95: 3106-3112. | Peichev, M. et al. (2000) Expression of VEGFR-2 and AC133 by circulating human CD34+ cells identifies a population of functional endothelial precursors. Blood 95: 952-958. | Cummings, B. J. et al. (2005) Human neural stem cells differentiate and promote locometer recovery in spinal cord-injured mice. Proc. Natl. Acad. Sci. U.S.A. 102: 14069-14074. | Galic, Z. et al. (2006) T lineage differentiation from human embryonic stem cells. Proc. Natl. Acad. Sci. U.S.A. 103: 11742-11747. | Uchida, N. et al. (2000) Direct isolation of human central nervous system stem cells. Proc. Natl. Acad. Sci. U.S.A. 97: 14720-14725. | Weigmann, A. et al. (1997) Prominin, a novel microvilli-specific polytopic membrane proteine of the apical surface of epithelial cells, is targeted to plasmalemmal protrusions of non-epithelial cells. Proc. Natl. Acad. Sci. U.S.A. 94: 12425-12430. | Estes, M. L. et al. (2010) Application of polychromatic flow cytometry to identify novel subsets of circulating cells with angiogenic potential. Cytometry A 77 (9): 831-839. | Park, T. S. et al. (2013) Efficient and simultaneous generation of hematopoietic and vascular progenitors from human induced pluripotent stem cells. Cytometry A 83 (1): 114-126. | Bussolati, B. et al. (2005) Isolation of renal progenitor cells from adult human kidney. Am. J. Pathol. 166: 545-555. | Buhring, H. J. et al. (1999) Expression of novel surface antigens on early hematopoietic cells. Ann. N. Y. Acad. Sci. 872: 25-39. | Immervoll, H. et al. (2008) Expression of the "stem cell marker" CD133 in pancreas and pancreatic ductal adenocarcinomas. BMC Cancer 8: 48. | Wong, C. K. E. et al. (2012) Levels of a subpopulation of platelets, but not circulating endothelial cells, predict early treatment failure in prostate cancer patients after prostatectomy. Br. J. Cancer 107 (9): 1564-1573. | Richardson, G. et al. (2004) CD133, a novel marker for human prostatic epithelial stem cells. J. Cell. Sci. 117: 3539-3545. | Walton, R. M. et al. (2013) Postnatal neural precursor cell regions in the rostral subventricular zone, hippocampal subgranular zone and cerebellum of the dog (Canis lupus familiaris). Histochem. Cell Biol. 139 (3): 415-429. | Fusi, A. et al. (2011) Expression of the stem cell markers nestin and CD133 on circulating melanoma cells. J. Invest. Dermatol. 131 (2): 487-494. | Thill, M. et al. (2004) Identification of a population of CD133+ precursor cells in the stroma of human cornea. Invest. Ophthalmol. Vis. Sci. 45: 3519. | Fonseca, A. V. et al. (2010) Polarization and migration of hematopoietic stem and progenitor cells rely on the RhoA/ROCK I pathway and an active reorganization of the microtubule network. J. Biol. Chem. 285 (41): 31661-31671. | Mak, A. B. et al. (2011) CD133 protein N-glycosylation processing contributes to cell surface recognition of the primitive cell marker AC133 epitope. J. Biol. Chem. 286 (47): 41046-41056. | Maxwell, S. A. et al. (2009) 14-3-3zeta mediates resistance of diffuse large B cell lymphoma to an anthracycline-based chemotherapeutic regimen. J. Biol. Chem. 284 (33): 22379-22389. | Piechaczek, C. (2001) CD133. J. Biol. Regul. Homeost. Agents 15: 101-102. | Margolis, D. J. et al. (2009) Phase I study of H5.020CMV.PDGF-beta to treat venous leg ulcer disease. Mol. Ther. 17 (10): 1822-1829. | Duda, D. G. et al. (2007) A protocol for phenotypic detection and enumeration of circulating endothelial cells and circulating progenitor cells in human blood. Nat. Protoc. 2 (4): 805-810. | Clark, P. A. et al. (2012) Activation of multiple ERBB family receptors mediates glioblastoma cancer stem-like cell resistance to EGFR-targeted inhibition. Neoplasia 14 (5): 420-428. | Lin, L. et al. (2009) The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-beta signaling. Oncogene 28 (7): 961-972. | Ferro, F. et al. (2012) Dental pulp stem cells differentiation reveals new insights in Oct4A dynamics. PLoS One 7 (7): e41774. | Fredebohm, J. et al. (2012) Establishment and characterization of a highly tumourigenic and cancer stem cell enriched pancreatic cancer cell line as a well defined model system. PLoS One 7 (11): e48503. | Balasubramanian, P. et al. (2013) AQP9 expression in glioblastoma multiforme tumors is limited to a small population of astrocytic cells and CD15+/CalB+ leukocytes. PLoS One 8 (9): e75764. | Metsuyanim, S. et al. (2009) Expression of stem cell markers in the human fetal kidney. PLoS One 4 (68): e6709. | Qi, Y. et al. (2012) Inhaled NO contributes to lung repair in piglets with acute respiratory distress syndrome via increasing circulating endothelial progenitor cells. PLoS One 7 (3): e33859. | Ye, X. et al. (2013) The effect of Heparin-VEGF multilayer on the biocompatibility of decellularized aortic valve with platelet and endothelial progenitor cells. PLoS One 8 (1): e54622. | Hu, Y. et al. (2013) Tumor-specific chromosome mis-segregation controls cancer plasticity by maintaining tumor heterogeneity. PLoS One 8 (11): e80898. | de Wynter, E. A. et al. (1998) CD34+AC133+ cells isolated from cord blood are highly enriched in long-term culture-initiating cells, NOD/SCID-repopulating cells and dendritic cell progenitors. Stem Cells 16: 387-396. | Alvarez, D. F. et al. (2008) Lung microvascular endothelium is enriched with progenitor cells that exhibit vasculogenic capacity. Am. J. Physiol. Lung Cell Mol. Physiol. 294 (3): L419-L430. | Rheinbay, E. et al. (2013) An aberrant transcription factor network essential for Wnt signaling and stem cell maintenance in glioblastoma. Cell Rep 3 (5): 1567-1579. | Behbod, F. et al. (2009) An intraductal human-in-mouse transplantation model mimics the subtypes of ductal carcinoma in situ. Breast Cancer Res. 11 (5): R66. | Steinmetz, N. F. et al. (2011) Two domains of vimentin are expressed on the surface of lymph node, bone and brain metastatic prostate cancer lines along with the putative stem cell marker proteins CD44 and CD133. Cancers (Basel) 3 (3): 2870-2885. | Liu, H. et al. (2013) Single-cell clones of liver cancer stem cells have the potential of differentiating into different types of tumor cells. Cell Death Dis 4: e857. | Czyz, M. et al. (2013) Parthenolide reduces the frequency of ABCB5-positive cells and clonogenic capacity of melanoma cells from anchorage independent melanospheres. Cancer Biol. Ther. 14 (2): 135-145. | Tsang, H. et al. (2013) Role of asymmetric methylarginine and connexin 43 in the regulation of pulmonary endothelial function. Pulm Circ 3 (3): 675-691. | Sun, Y. et al. (2014) Slug overexpression induces stemness and promotes hepatocellular carcinoma cell invasion and metastasis. Oncol Lett 7 (6): 1936-1940. | Schiffer, D. et al. (2014) Stem cell niches in glioblastoma: a neuropathological view. Biomed Res Int 2014: 725921.
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-Straße 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197

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