GAD65, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Edit | |
|---|---|
| Antigenic Specificity | GAD65, Human |
| Clone | REAL1083 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | n/a |
| Format | phycoerythrin (PE) conjugate |
| Size | 200 µL |
| Concentration | n/a |
| Applications | MICS (MACSima Imaging Cyclic Staining), Immunohistochemistry, Immunofluorescence |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | GAD65 Antibody, anti-human, PE, REAdye_lease™. Clone REAL1083 is an antibody fragment derived from the full GAD65 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity. | Clone REAL1083 recognizes the GAD65 enzyme, also known as Glutamate decarboxylase 2, and belongs to the group II decarboxylase family. GAD65 catalyzes the production of GABA (gamma-aminobutyric acid) from L-glutamic acid for neurotransmission. GAD65 has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. The GAD65 gene may also play a role in the stiff person syndrome, Type 1 diabetes (T1D), cerebellar ataxia and other neurological disorders. | For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675). | |
| Immunogen | n/a |
| Other Names | GAD-65, GAD2, Glutamate decarboxylase 2, 65 kDa glutamic acid decarboxylase, Glutamate decarboxylase 65 kDa isoform |
| Gene, Accession # | n/a |
| Catalog # | 130-129-276 |
| Price | $520 |
| Order / More Info | GAD65, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Langendorf, C. G. et al. (2013) Structural characterization of the mechanism through which human glutamic acid decarboxylase auto-activates. Biosci. Rep. 33 (1): 137-144. | Kanaan, J. et al. (2015) Compartmentalization of GABA synthesis by GAD67 differs between pancreatic beta cells and neuron. PLoS One 10 (2): e0117130. | Dade, M. et al. (2020) Neurological Syndromes Associated with Anti-GAD Antibodies. Int J Mol Sci 21 (10): 3701. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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