Dectin-1, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | Dectin-1, Mouse |
| Clone | REA154 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | biotin conjugate |
| Size | 9 µg in 300 µL |
| Concentration | 1:10 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Dectin-1 Antibody, anti-mouse, Biotin, REAfinity™. Clone REA154 recognizes murine dectin-1, which is approximately 40 kDa type II transmembrane protein, also known as mouse beta-glucan receptor or CLEC7A. It promotes the phagocytosis of intact yeasts and glucan particles such as β-1,3-linked and β-1,6-glucans, thus playing an important role in anti-fungal immunity. Neutrophils and macrophages express relatively higher levels of dectin-1 as compared to dendritic cells and subpopulation of T cells. In cooperation with TLR2 and TLR4, dectin-1 leads to cytokine production in human macrophages and monocytes. | Additional information: Clone REA154 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | CLEC7A, BGR, CLECSF12, Beta-GR, βGR |
| Gene, Accession # | Gene ID: 56644 |
| Catalog # | 130-102-035 |
| Price | $30 |
| Order / More Info | Dectin-1, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Taylor, P. R. et al. (2002) The beta-glucan receptor, Dectin-1, is predominantly expressed on the surface of cells of the monocyte/macrophage and neutrophil lineages. J Immunol 169: 3876-3882. | Brown, G. D. et al. (2002) Dectin-1 is a major β-glucan receptor on macrophages. J. Exp. Med. 196 (3): 407-412. | Ferwerda, G. et al. (2008) Dectin-1 synergizes with TLR2 and TLR4 for cytokine production in human primary monocytes and macrophages. Cell. Microbiol. 10 (10): 2058-2066. | Ariizumi, K. et al. (2000) Identification of a novel, dendritic cell-associated molecule, Dectin-1, by subtractive cDNA cloning. J. Biol. Chem. 275: 20157-20167. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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