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Antigenic Specificity | Integrin β5, Human |
Clone | REA718 |
Host Species | Recombinant Human |
Reactive Species | human |
Isotype | IgG1 |
Format | phycoerythrin (PE) conjugate |
Size | 100 tests in 200 µL |
Concentration | 1:50 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Integrin β5 Antibody, anti-human, PE, REAfinity™. Clone REA718 recognizes the human integrin β5 antigen, a 95 kDa glycoprotein single-pass type I membrane protein. Integrins are a family of transmembrane receptors that mediate adhesion of cells to extracellular matrices, as well as intercellular interactions. These interactions transduce signals that control complex cell functions such as proliferation, differentiation, and survival, and require the regulation of gene expression. Integrins are heterodimeric glycoprotein receptors and exist as non-covalently bound α and β subunits. The integrin αV/β5 heterodimer is found on many types of tissue cells, such as epithelial cells, endothelial cells, keratinocytes, and osteoblastic cells. It is a receptor for fibronectin and vitronectin and acts as a receptor for adenovirus type C. | Additional information: Clone REA718 displays negligible binding to Fc receptors. |
Immunogen | n/a |
Other Names | integrin b5, integrin beta 5, ITGB5 |
Gene, Accession # | Gene ID: 3693 |
Catalog # | 130-111-215 |
Price | $310 |
Order / More Info | Integrin β5, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Kim, J. P. et al. (1994) Vitronectin-driven human keratinocyte locomotion is mediated by the alpha v beta 5 integrin receptor. J. Biol. Chem. 269 (43): 26926-26932. | Zhang, H. et al. (2004) Myosin-X provides a motor-based link between integrins and the cytoskeleton. Nat. Cell Biol. 2004 (6): 523-531. | Lyle, C. et al. (2010) Integrin alphavbeta5 is a primary receptor for adenovirus in CAR-negative cells. J. Virol. 7 (148): 1743-1745. |